TSH: the Thyroid Feedback Loop

By Dr Kelly

September 1, 2018

The TSH feedback loop is a regulatory mechanism that helps maintain normal levels of thyroid hormones in the body. Here's how it works:

  1. The hypothalamus in the brain senses low levels of thyroid hormones in the bloodstream and releases thyrotropin-releasing hormone (TRH).

  2. TRH travels to the pituitary gland, also located in the brain, and stimulates the release of thyroid-stimulating hormone (TSH).

  3. TSH travels through the bloodstream to the thyroid gland, which is located in the neck. TSH stimulates the thyroid gland to produce and release more thyroid hormones, including thyroxine (T4) and triiodothyronine (T3).

  4. As the levels of thyroid hormones increase in the bloodstream, they send a negative feedback signal to the hypothalamus and pituitary gland to decrease the production and release of TRH and TSH, respectively. This helps prevent excessive production of thyroid hormones.

  5. If the levels of thyroid hormones in the bloodstream become too high, they can also inhibit the production and release of TRH and TSH. This helps maintain the balance of thyroid hormones in the body.

Overall, the TSH feedback loop helps regulate the production and release of thyroid hormones to ensure that the body has the appropriate levels of these hormones to support normal metabolism, growth, and development.

About the author

Dr. Kelly has 25 years of expert medical experience caring for the sickest of the sick people in critical care (including ICU, Heart surgery, Heart & Lung transplant surgery, as well as cardiology). She is a clinical specialist who has taken care of and trained others to care for the critically ill/the elderly and developed many screening and preventative programs to help improve the health of the population. The reality is that most people just don't have to be that sick. or stay that sick. So, Dr. Kelly decided to change the focus of the care she provided: to prevent, reverse and restore the health of individuals.

Dr. Kelly

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